12.OCT.2018 7 MIN READ | 7 MIN READ

Is that pain in your chest caused by a gastric problem? Dr Tan Chi Chiu, gastroenterologist at Gleneagles Hospital, explains how digestive conditions can cause chest discomfort and when you should seek medical help.

There are many causes of chest pain that can arise from the digestive tract, particularly in the oesophagus and the muscular tube that transports food from the mouth to the stomach.

Pain in the oesophagus can be felt in the centre of the chest, from the epigastrium (top of the soft part of the abdomen, below the breastbone) up to the throat. Oesophageal pain can also radiate to either side of the chest. When it radiates to the lower left part of the chest, the pain is sometimes misinterpreted as coming from the heart, such as during angina or a heart attack.

If you have concerns about your digestive health, speak to a specialist.

Oesophageal pain can have many triggers. Common inflammatory causes include:

Gastric problems causing chest pain - GERD
Gastro-oesophageal reflux disease (GERD)

This digestive disorder is caused when excessive acid from the stomach, together with other caustic chemicals – such as the digestive enzyme pepsin and bile that refluxes into the stomach from the duodenum (early part of the small intestine) – flows back into the oesophagus. When these chemicals rise above the gastro-oesophageal junction (a physiological valve separating the oesophagus and stomach), they irritate and inflame the lining of the lower oesophagus.

Symptoms of GERD include heartburn, a burning or painful sensation, or a feeling of pressure in the centre of the chest, as well as regurgitation of acidic stomach contents to the throat or mouth, which can cause a sore throat and leave a sour taste in the mouth. The lower oesophagus could also suffer damage, ranging from redness or mild inflammation to severe erosions and ulcerations, bleeding and scarring with stricture (tightening) of the oesophagus. This can lead to swallowing difficulties and pain.

• Eosinophilic esophagitis (EoE)

A variant of GERD is an inflammation of the oesophagus that is thought to be related to allergies to various food groups or other environmental allergens. As part of the body’s allergic reaction, white blood cells known as eosinophils infiltrate the lining of the oesophagus. The condition, known as eosinophilic esophagitis, causes heartburn and swelling of the lower oesophageal lining and narrowing of the oesophagus. As with GERD, this makes swallowing difficult and painful.

Other less common inflammatory causes include:

• Swallowing of scalding fluids or caustic liquids such as acids or alkalis

This can trigger oesophagitis, or inflammation of the oesophageal lining.

• Radiotherapy to the chest for cancer

Sometimes, the radiation can burn the oesophagus as an unintended consequence.

Food that is lodged in the oesophagus can cause chest pain and odynophagia, or painful swallowing. Common causes are:

Gastric problems causing chest pain - Oesophageal cancer
• Cancer of the oesophagus

Cancer can develop in the squamous cells of the upper and mid oesophagus or the columnar epithelial cells of the lower oesophagus, adjacent with the stomach lining. The former, which is related to smoking and drinking scalding liquids, is becoming less common. On the other hand, the latter, which is related to acid reflux and smoking, is becoming more common. In cancer which grows larger over time, the difficulty in swallowing, or dysphagia, is progressive. At first, it is difficult to swallow large, hard pieces of food, and eventually, even drinking water can become impossible.

• Cancer of the upper stomach

This can block the entry of food into the stomach. When food backs up into the oesophagus, the pressure can cause pain in the chest.

• Oesophagitis

As noted above, the oesophagus can narrow either due to swelling of the lining (EoE) or scarring by severe acid reflux. Food that is stuck in the oesophagus can also cause pain in this instance.

• Motility disorders

Motility is a term used to describe the contraction of muscles in the gastrointestinal tract. Motility disorders such as ‘diffuse oesophageal spasm’ or ‘nutcracker oesophagus’ cause strong disorganised contractions in the oesophagus that make swallowing difficult and painful.

A less common motility disorder is achalasia, a condition in which the muscles in the lower part of the oesophagus fails to relax to allow food to pass through as you swallow. Achalasia may occur in childhood or in adults. Some people are born with it while others develop the condition when another disease damages the nerves inside their oesophagus.

• Plummer-Vinson syndrome or Paterson-Kelly syndrome

Also rare are oesophageal rings or webs – tissue growths which can develop in the upper or lower oesophagus. This often occurs from birth but is sometimes associated with reflux or iron deficiency anaemia. Plummer-Vinson syndrome or Paterson-Kelly syndrome often presents with a triad of symptoms – iron deficiency anaemia, dysphagia or difficulty swallowing, and an oesophageal web, which can be seen on a barium swallow test (an imaging test that uses x-rays to examine your upper gastrointestinal tract).

Chest pain from the oesophagus may also be caused by medicines:

Gastric problems causing chest pain - Medication
• Aspirin or drugs in the class of nonsteroidal anti-inflammatory drugs (NSAIDs)

These medicines, such as Ibuprofen, can injure the lining of the entire digestive tract and cause inflammation in the oesophagus.

• Failure to swallow medicine properly

Some drugs may also become wedged in the oesophagus if not swallowed properly. Common culprits include potassium tablets, large multivitamin pills, and acne medication such as tetracycline and doxycycline. If you swallow pills lying down or fail to drink enough water with the medicine, caustic chemicals in the drugs can injure the oesophagus. In such cases, chest pain usually sets in several hours after taking the medication. Should the doctor conduct an endoscopy, circumferential ulcers can be found in the mid to lower oesophagus where the pill was lodged.

Foreign objects that are lodged in the oesophagus can also cause chest pain.

Children may swallow toys or other objects, while adults sometimes also inadvertently swallow foreign objects like toothpicks. (This can happen if you neglect to remove the toothpick in a cocktail snack and swallow it quickly – often in a semi-drunken state!)

Infections of the oesophagus can also cause pain.

However, oesophageal infections are uncommon and more likely occur in people with compromised immune systems, such as those who have diabetes mellitus, HIV, or are taking immunosuppressive drugs for other conditions. Infections caused by yeast (candida) or herpes viruses can cause inflammation in the oesophagus with a lot of pain.

When to seek help

Gastric problems causing chest pain - Seek help
As a general rule, chest pain that is severe, persistent or both, should receive medical attention. A cardiac cause, such as a heart attack, must be excluded quickly. After that, other less dangerous causes can be sought.

If chest pain is mild, related to food and easily relieved by taking antacids (medication that neutralises stomach acidity), then perhaps it is acid-mediated and there is no urgency.

However, if simple measures such as antacids do not provide relief, the pain is getting more severe or becoming persistent, you should see a doctor soon. As a rule of thumb, the more severe the pain, the more urgent it is to see a doctor, or even go to an emergency room.


To find out if a digestive disorder is causing your chest pain, your gastroenterologist may conduct an endoscopy to examine your oesophagus, stomach or small intestine. It is a non-surgical procedure where an endoscope, a flexible tube with a light and camera attached to it, is passed through the mouth and throat into the oesophagus.

The advanced field of endoscopy today makes it possible to diagnose causes of upper digestive tract symptoms, such as chest pain. If therapeutic measures are required, there are also many techniques readily available. For example, it is possible to dilate a narrowed part of the oesophagus, use a laser or Argon plasma beam to shave away local obstruction caused by oesophageal cancer, and use instruments to retrieve food or a foreign object lodged in the oesophagus.

In terms of diagnosing motility disorders, where visual findings by endoscopy may not yield enough information, there are now sophisticated devices for measuring pressure in various parts of the oesophagus, acid reflux into the oesophagus, and the flow of fluids up the oesophagus. Analysing these measurements can give doctors insight into the type of motility disorder that is causing your symptoms.

To get to the bottom of your chest pain or digestive problems, make an appointment with a specialist.


Article reviewed by Dr Tan Chi Chiu, gastroenterologist at Gleneagles Hospital

Tan Chi Chiu
Gleneagles Hospital

Dr Tan Chi Chiu graduated from the National University of Singapore in 1983. He pursued specialist training in Internal Medicine and obtained his Memberships of the Royal Colleges of Physicians of the United Kingdom and Ireland, as well as his Master of Medicine in Internal Medicine in 1988. Dr Tan specialised in Gastroenterology and was accorded the Fellowship of the Academy of Medicine in Gastroenterology in 1993 and recognised by the Ministry of Health as a specialist in Gastroenterology. He was further conferred the Fellowships of the Royal Colleges of Physicians of Edinburgh and London in 1996 and 1998 respectively.